Table 3. Subgroup Analysis by Unit Type on the Proportion of Prescribed Venous Thromboembolism Prophylaxis Medication Doses Misseda .
| Intervention Period | Surgical Units | Medical Units | ||||||
|---|---|---|---|---|---|---|---|---|
| Intervention Group | Control Group | OR Intervention vs Control (95% CI) | P Value | Intervention Group | Control Group | OR Intervention vs Control (95% CI) | P Value | |
| Any Missed Dose | ||||||||
| Preintervention, % (95% CI) | 5.0 (3.1-8.2) | 9.3 (6.8-12.6) | 0.50 (0.26-0.98) | .04 | 16.8 (10.3-27.2) | 18.3 (14.1-23.8) | 0.89 (0.47-1.69) | .72 |
| Postintervention, % (95% CI) | 2.8 (1.7-4.6) | 8.0 (5.9-10.8) | 0.32 (0.16-0.63) | .001 | 10.7 (6.6-17.3) | 19.1 (14.8-24.7) | 0.49 (0.26-0.92) | .03 |
| OR postintervention vs preintervention (95% CI) | 0.54 (0.42-0.69) | 0.84 (0.74-0.95) | NA | NA | 0.58 (0.47-0.72) | 1.06 (0.96-1.18) | NA | NA |
| P valueb | <.001 | .01 | NA | NA | <.001 | .24 | NA | NA |
| Patient Refusal | ||||||||
| Preintervention, % (95% CI) | 2.5 (1.3-4.9) | 4.6 (3.0-6.9) | 0.52 (0.22-1.25) | .15 | 14.1 (7.6-26.4) | 14.5 (10.4-20.3) | 0.96 (0.44-2.13) | .92 |
| Postintervention, % (95% CI) | 1.3 (0.6-2.6) | 3.7 (2.5-5.5) | 0.34 (0.14-0.81) | .02 | 8.3 (4.4-15.4) | 15.1 (10.8-21.0) | 0.49 (0.22-1.08) | .08 |
| OR postintervention vs preintervention (95% CI) | 0.50 (0.34-0.75) | 0.79 (0.66-0.93) | NA | NA | 0.54 (0.43-0.68) | 1.05 (0.94-1.18) | NA | NA |
| P valueb | <.001 | .01 | NA | NA | <.001 | .36 | NA | NA |
| Other Reasons Than Refusal | ||||||||
| Preintervention, % (95% CI) | 2.3 (1.3-3.9) | 3.8 (2.7-5.5) | 0.56 (0.28-1.11) | .10 | 2.2 (1.2-4.0) | 3.1 (2.3-4.2) | 0.71 (0.35-1.43) | .34 |
| Postintervention, % (95% CI) | 1.3 (0.8-2.4) | 3.5 (2.5-5.0) | 0.37 (0.18-0.74) | .01 | 2.1 (1.2-3.8) | 3.3 (2.4-4.4) | 0.63 (0.31-1.26) | .19 |
| OR postintervention vs preintervention (95% CI) | 0.59 (0.44-0.80) | 0.91 (0.78-1.06) | NA | NA | 0.94 (0.64-1.37) | 1.06 (0.89-1.26) | NA | NA |
| P valueb | <.001 | .23 | NA | NA | .73 | .49 | NA | NA |
Abbreviations: NA, not applicable; OR, odds ratio.
Two-way interactions were performed including preintervention vs postintervention periods and control vs intervention units for surgical units (OR for any missed dose, 0.64 [95% CI, 0.48-0.85; P = .002]; OR for patient refusal, 0.64 [95% CI, 0.41-1.00; P = .05]; and OR for reasons other than refusal, 0.65 [95% CI, 0.47-0.91; P = .01]) and medical units (OR for any missed dose, 0.55 [95% CI, 0.44-0.69; P ≤ .001]; OR for patient refusal, 0.51 [95% CI, 0.39-0.66; P ≤ .001]; and OR for reasons other than refusal, 0.88 [95% CI, 0.57-1.35; P = .56]). Three-way interactions were performed including preintervention vs postintervention periods, control vs intervention units, and surgical vs medical unit with no significant differences observed (OR for any missed dose, 0.86 [95% CI, 0.60-1.23; P = .41]; OR for patient refusal, 0.80 [95% CI, 0.48-1.33; P = .38]; and OR for reasons other than refusal, 1.35 [95% CI, 0.78-2.33; P = .29]).
Calculated using multiple outputation of the generalized linear mixed-effects models with the binomial family and a logit link.