Figure. Change in Each Transdiagnostic Psychopathology Domain by Change in Life Stress and Level of Childhood Adversity.

Changes in each transdiagnostic psychopathology domain and life stress were measured based on estimated factor scores at waves 1 and 2 of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC), derived from standardized latent variables (ie, with a mean of 0 and a variance of 1). The number of individuals corresponding to the different values of observed change scores in life stress was 158 (0.4%) with less than −2, 2504 (7.3%) with −2 to less than −1, 10 236 (29.7%) with −1 to less than 0, 7563 (21.9%) with 0, 10 872 (31.6%) with more than 0 to 1, 2865 (8.3%) with more than 1 to 2, and 260 (0.8%) with more than 2. All analyses were controlled for age, sex, race/ethnicity minority status, annual personal income, and educational level. Error bars depict standard errors for the estimated marginal means. Significance levels were adjusted for a reportwide false discovery rate of 5% using the Benjamini-Hochberg procedure,⁴² which corresponded to P ≤ .031.

^aIndicates P ≤ .031 between all adverse childhood experience groups.

^bIndicates P ≤ .031 between participants with no childhood adversity and those with 1 to 2 and 3 or more adverse childhood experiences, but not between the groups with 1 to 2 and 3 or more adverse childhood experiences.