Table 2. Estimated Fixed Effects of Change in Each Transdiagnostic Psychopathology Domaina.
| Construct | Transdiagnostic Psychopathology Domain, Estimated Fixed Effects (95% CI)b | |||
|---|---|---|---|---|
| Internalizing | Externalizingc | General Psychopathologyc | ||
| Fearc | Distressc | |||
| Intercept | 0.29 (1.28 to 0.31) | 0.33 (0.31 to 0.34) | 0.34 (0.33 to 0.36) | 0.33 (0.32 to 0.34) |
| Life stress | 0.23 (0.21 to 0.24) | 0.27 (0.26 to 0.28) | 0.23 (0.22 to 0.24) | 0.26 (0.25 to 0.28) |
| Childhood Adversity | ||||
| No vs high exposure | –0.20 (–0.21 to –0.18) | –0.21 (–0.22 to –0.20) | –0.21 (–0.22 to –0.20) | –0.22 (–0.23 to –0.21) |
| Low vs high exposure | –0.12 (–0.14 to –0.11) | –0.13 (–0.14 to –0.12) | –0.13 (–0.14 to –0.11) | –0.14 (–0.15 to –0.12) |
| Stress by Childhood Adversity | ||||
| No vs high exposure | –0.10 (–0.11 to –0.08) | –0.12 (–0.14 to –0.11) | –0.11 (–0.12 to –0.09) | –0.12 (–0.14 to –0.10) |
| Low vs high exposure | –0.05 (–0.07 to –0.04) | –0.07 (–0.08 to –0.05) | –0.06 (–0.07 to –0.04) | –0.06 (–0.08 to –0.05) |
Includes 34 458 participants. These values represent the estimated associations between each indicator and dependent variable after controlling for age, sex, race/ethnicity minority status, annual personal income, and educational level. Life stress (an indicator) and psychopathology (the dependent variables) are based on estimated factor scores derived from standardized latent variables (ie, with a mean of 0 and a variance of 1).
Each transdiagnostic psychopathology domain was analyzed separately.
All of the type III tests of fixed effects and the estimates of the fixed effect (ie, the global F test for the effect and the 2-tailed t test for the different levels of categorical effects) reached significance after adjusting for a reportwide false discovery rate of 5% using the Benjamini-Hochberg procedure,42 which corresponded to P ≤ .031.