Table. Sensitivity, Specificity, and NPV of 3-Gene Tuberculosis Score as a Triage Test for Active Tuberculosis and a Test for Progression From Latent Mycobacterium Tuberculosis Infection to Active Tuberculosis.
| Cohort | % | AUROC (95% CI) | ||
|---|---|---|---|---|
| Sensitivity | Specificity | NPV at 4% Prevalence | ||
| WHO test name | ||||
| Triage test | ||||
| BASS | 90.91 | 68.75 | 99.29 | 0.87 (0.79-0.94) |
| ACS, 0-7 d | 89.47 | 63.37 | 99.13 | 0.86 (0.77-0.96) |
| CTRC | 90.11 | 89.19 | 99.42 | 0.94 (0.88-0.99) |
| Overall | 90 | 70 | 99.3 | |
| Progression test | ||||
| ACS, 8-180 d | 86 | 84 | 98.63 | 0.86 (0.70-1.00) |
Abbreviations: ACS, Adolescent Cohort Study; AUROC, area under receiver operating characteristic curve; BASS, Brazil Active Screen Study; CTRC, Catalysis Treatment Response Cohort; NPV, negative predictive value; WHO, World Health Organization.