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. 2018 Oct 5;1(6):e183115. doi: 10.1001/jamanetworkopen.2018.3115

Figure 5. Improvement in the Ability to Stratify Patients for Risk of Recurrence After Curative Surgery With the Addition of ZEB2 Expression Status to the TNM Staging System.

Figure 5.

A and B, Receiver operating characteristic curves were generated with and without addition of ZEB2 to the TNM staging system to evaluate any improvement in incremental area under the curve (iAUC). B, Improvement in iAUC secondary to the addition of ZEB2 as a histogram. Error bars indicate 95% CI. C and D, Kaplan-Meier curves show increased separation and stratification when ZEB2 is added to the nomogram. Patients were stratified as high risk or low risk based on scores generated from the nomogram. C, Results of the risk score alone. D, Results with the addition of ZEB2 scoring. P values were calculated using the log-rank test. E, Visual representation of the nomogram used to estimate risk of early distant recurrence. EMVI indicates extramural vascular invasion.