Table 2. Univariable Analysis of Putative Clinicopathological Variables.
| Baseline Characteristics | Hazard Ratio (95% CI) | P Value |
|---|---|---|
| Age, y | 1.01 (1.01-1.02) | <.001 |
| BMI | 0.95 (0.82-0.97) | <.001 |
| NLR | 1.02 (1.02-1.03) | <.001 |
| Sex | ||
| Female | 1 [Reference] | |
| Male | 1.69 (1.40-2.04) | <.001 |
| Categorized age, y | ||
| <60 | 1 [Reference] | |
| 60-70 | 1.03 (0.82-1.28) | .79 |
| >70 | 1.59 (1.28-1.99) | <.001 |
| Categorized BMI | ||
| <18.5 | 2.84 (1.94-4.16) | <.001 |
| 18.5 to <25 | 1.43 (1.15-1.78) | .001 |
| ≥25 | 1 [Reference] | |
| Categorized NLR | ||
| <3 | 1 [Reference] | |
| 3 to <5 | 1.23 (0.96-1.58) | .10 |
| ≥5 | 2.31 (1.84-2.89) | <.001 |
| Histology | ||
| Small cell lung cancer | 1 [Reference] | |
| Non–small cell lung cancer | 0.40 (0.28-0.57) | <.001 |
| Squamous cell carcinoma | 0.51 (0.33-0.79) | .003 |
| Adenocarcinoma | 0.36 (0.25-0.52) | <.001 |
| Othersa | 0.46 (0.31-0.67) | <.001 |
| EGFR mutation status | ||
| Unknown | 1 [Reference] | |
| Positive | 0.60 (0.43-0.84) | .003 |
| Negative | 0.97 (0.66-1.42) | .86 |
| Nonbone metastasis | ||
| Absent | 1 [Reference] | |
| Present | 0.89 (0.69-1.15) | .38 |
| Performance statusb | ||
| KPS 70-100, ECOG 0-1 | 1 [Reference] | |
| KPS 10-60, ECOG 2-4 | 1.26 (1.04-1.52) | .02 |
| Smoking history | ||
| Ever smoker | 1 [Reference] | |
| Never smoker | 1.79 (1.48-2.15) | <.001 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); ECOG, Eastern Cooperative Oncology Group; EGFR, epidermal growth factor receptor; KPS, Karnofsky Performance Status; NLR, neutrophil to lymphocyte ratio.
a
Other histologies include large cell carcinoma, adenosquamous carcinoma, and non–small cell carcinoma not otherwise specified.
b
Possible KPS scores range from 0 to 100, with higher scores indicating better performance status (100 denoting perfect health and 0 denoting death). Possible ECOG scores range from 0 to 5, with higher scores indicating worse performance status (0 denoting perfect health and 5 denoting death).