Table 2. Baseline Characteristics of Patients With Early-Onset Atrial Fibrillation and Non–Early-Onset Atrial Fibrillation Based on a Verified History of Atrial Fibrillation in First-Degree Relatives.
| Family History | First-Degree Relative With Atrial Fibrillation | |||||||
|---|---|---|---|---|---|---|---|---|
| EOAF (n = 74) | Non-EOAF (n = 590) | |||||||
| Yes (n = 24) | No (n = 50) | Difference (95% CI) | P Value | Yes (n = 63) | No (n = 527) | Difference (95% CI) | P Value | |
| Age at onset, mean (SD), y | 46 (11) | 50 (10) | −4.7 (−9.4 to −0.77) | .09 | 61 (10) | 63 (11) | −1.9 (−5.0 to 0.9) | .18 |
| Male, No. (%) | 13 (54) | 31 (62) | −0.08 (−0.32 to 0.16) | .52 | 35 (56) | 328 (62) | −0.06 (−0.20 to 0.06) | .30 |
| Ethnicity, No. (%) | ||||||||
| European American | 15 (62) | 28 (56) | 0.06 (−0.17 to 0.30) | .87 | 33 (52) | 180 (34) | 0.35 (9.24 to 0.48) | <.001 |
| African American | 6 (25) | 15 (30) | −0.05 (−0.26 to 0.16) | 21 (34) | 221 (42) | −0.22 (−0.33 to −0.11) | ||
| Hispanic/Latino | 3 (13) | 7 (14) | −0.01 (−0.18 to 0.15) | 9 (14) | 126 (24) | −0.13 (−0.22 to −0.06) | ||
| BMI, mean (SD) | 36 (8.9) | 32 (8.0) | 4.1 (0.01 to 8.2) | .05 | 35 (8.4) | 33 (8.5) | 1.5 (−3.8 to 0.71) | .17 |
| Hypertension, No. (%) | 9 (38) | 17 (34) | 0.04 (−0.20 to 0.27) | .76 | 52 (83) | 453 (86) | −0.03 (−0.13 to 0.06) | .47 |
| Coronary artery disease, No. (%) | 0 | 0 | 0 | >.99 | 40 (64) | 345 (66) | −0.02 (−0.15 to 0.11) | .76 |
| Diabetes mellitus, No. (%) | 0 | 0 | 0 | >.99 | 19 (30) | 191 (36) | −0.06 (−0.18 to 0.06) | .34 |
| Left ventricular ejection fraction, mean (SD), % | 56 (10) | 56 (10) | −0.6 (−5.4 to 4.3) | .81 | 52 (13) | 50 (15) | 2.5 (−1.3 to 6.3) | .19 |
| Congestive heart failure, No. (%) | 0 | 0 | 0 | >.99 | 23 (63) | 189 (36) | 0.01 (−0.12 to 0.13) | .92 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); EOAF, early-onset atrial fibrillation; non-EOAF, non–early-onset atrial fibrillation.