Table 2. Development of the Primary Cardiovascular Disease Composite Outcome of Hospitalization for the Main Analysis and Additional Analysis 1^a .

Outcome	No. of Events		Incidence Rate per 1000 Person-Years (95% CI)			HR (95% CI)
	Exposedb	Comparisonc	Exposed	Comparison	Rate Difference	Unadjusted	Adjustedd
Primary outcomee	914	7516	1.21 (1.13 to 1.28)	0.99 (0.97 to 1.01)	0.22 (0.14 to 0.30)	1.23 (1.15 to 1.32)	1.15 (1.07 to 1.23)
Primary outcome components
Myocardial infarction	266	2224	0.35 (0.31 to 0.39)	0.29 (0.28 to 0.30)	0.06 (0.01 to 0.10)	1.21 (1.06 to 1.37)	1.12 (0.98 to 1.28)
CABG or PCI	235	1911	0.31 (0.27 to 0.35)	0.25 (0.24 to 0.26)	0.06 (0.02 to 0.10)	1.24 (1.08 to 1.42)	1.12 (0.97 to 1.29)
Stroke	592	4841	0.78 (0.72 to 0.84)	0.64 (0.62 to 0.65)	0.14 (0.08 to 0.21)	1.23 (1.13 to 1.34)	1.16 (1.06 to 1.27)
Other cardiovascular outcomes
Unstable angina	787	6989	1.04 (0.96 to 1.11)	0.92 (0.90 to 0.94)	0.12 (0.04 to 0.19)	1.13 (1.05 to 1.22)	1.08 (1.00 to 1.16)
Congestive heart failure	219	1574	0.29 (0.25 to 0.32)	0.21 (0.20 to 0.22)	0.08 (0.04 to 0.12)	1.41 (1.22 to 1.62)	1.28 (1.10 to 1.48)
Atrial fibrillation	374	3277	0.49 (0.44 to 0.54)	0.43 (0.41 to 0.44)	0.06 (0.01 to 0.11)	1.15 (1.03 to 1.28)	1.10 (0.99 to 1.23)
Peripheral artery disease	255	1887	0.33 (0.29 to 0.38)	0.25 (0.24 to 0.26)	0.09 (0.04 to 0.13)	1.36 (1.19 to 1.55)	1.25 (1.09 to 1.43)
Ischemic heart disease	788	7017	1.04 (0.96 to 1.11)	0.92 (0.90 to 0.94)	0.12 (0.04 to 0.19)	1.13 (1.05 to 1.22)	1.07 (1.00 to 1.16)
Aortic aneurysm	14	109	0.02 (0.01 to 0.03)	0.01 (0.01 to 0.02)	0.00 (−0.01 to 0.01)	1.28 (0.73 to 2.23)	1.28 (0.73 to 2.25)

Abbreviations: CABG, coronary artery bypass graft; HR, hazard ratio; PCI, percutaneous coronary intervention.

^aMain analysis: acute myocardial infarction, coronary artery revascularization, or acute stroke; additional analysis: other various cardiovascular outcomes.

^bNumber at risk excludes mothers with a history of an event prior to the infant’s birth: primary composite outcome (42 893), myocardial infarction (42 939), stroke (42 898), CABG or PCI (42 942), unstable angina (42 923), congestive heart failure (42 924), atrial fibrillation (42 922), peripheral artery disease (42 931), ischemic heart disease (42 920), and aortic aneurysm (42 940).

^cNumber at risk excludes mothers with history of event prior to infant’s birth: primary composite outcome (428 051), myocardial infarction (428 366), stroke (428 092), CABG or PCI (428 386), unstable angina (428 279), congestive heart failure (428 316), atrial fibrillation (428 237), peripheral artery disease (428 280), ischemic heart disease (428 266), and aortic aneurysm (428 391).

^dAdjusted for matching variables and maternal demographics (marital status, immigration status), socioeconomic status (income quartile, educational level), previous maternal health status (diabetes, modified Charlson Comorbidity Index score, chronic hypertension, history of alcohol-related disease, and depression), previous spontaneous abortion, and pregnancy complications.

^eComposite cardiovascular disease outcome of hospitalization for myocardial infarction, CABG or PCI, or acute stroke.