Table 3. Development of the Cardiovascular Disease Composite Outcome of Hospitalization for Additional Analysis 2 and 3^a .

Analysis	No. of Events/No. of Women at Risk		Incidence Rate per 1000 Person-Years (95% CI)			HR (95% CI)
	Exposed	Comparison	Exposed	Comparison	Rate Difference	Unadjusted	Adjustedb
Overall	914/42 893	7516/428 051	1.21 (1.13 to 1.28)	0.99 (0.97 to 1.01)	0.22 (0.14 to 0.30)	1.23 (1.15 to 1.32)	1.15 (1.07 to 1.23)
Additional analysis 2
Major congenital anomaly subgroup
Multiorgan	90/3837	609/38 303	1.42 (1.13 to 1.71)	0.95 (0.87 to 1.03)	0.47 (0.17 to 0.77)	1.50 (1.20 to 1.87)	1.37 (1.08 to 1.72)
Single-organ	824/39 056	6907/389 748	1.19 (1.10 to 1.27)	0.99 (0.97 to 1.02)	0.19 (0.11 to 0.28)	1.20 (1.12 to 1.30)	1.13 (1.05 to 1.22)
Additional analysis 3
Follow-up time, yc
0 to 10	174/42 893	1189/428 051	0.47 (0.40 to 0.54)	0.32 (0.31 to 0.34)	0.15 (0.08 to 0.22)	1.47 (1.25 to 1.72)	1.30 (1.10 to 1.54)
>10 to 20	343/30 728	2766/307 667	1.37 (1.23 to 1.52)	1.10 (1.06 to 1.14)	0.27 (0.12 to 0.42)	1.25 (1.12 to 1.40)	1.16 (1.03 to 1.30)
>20 to 35	397/19 218	3561/193 625	2.81 (2.54 to 3.09)	2.50 (2.42 to 2.58)	0.32 (0.03 to 0.60)	1.13 (1.02 to 1.26)	1.08 (0.98 to 1.21)
Year of birth
1979 to 1993	736/20 232	6218/202 133	1.37 (1.27 to 1.47)	1.15 (1.12 to 1.18)	0.22 (0.11 to 0.32)	1.19 (1.11 to 1.29)	1.13 (1.05 to 1.22)
1994 to 2003d	142/11 178	1083/111 605	0.86 (0.72 to 1.01)	0.66 (0.62 to 0.70)	0.21 (0.06 to 0.35)	1.33 (1.11 to 1.58)	1.19 (0.99 to 1.43)
2004 to 2013e	36/11 483	215/114 313	0.64 (0.43 to 0.85)	0.38 (0.33 to 0.43)	0.26 (0.04 to 0.47)	1.72 (1.20 to 2.45)	1.36 (0.92 to 2.02)
Gestational age at birth, wkf
<37	160/5433	488/18 772	1.86 (1.57 to 2.15)	1.54 (1.40 to 1.67)	0.32 (0.00 to 0.64)	1.23 (1.03 to 1.47)	1.15 (0.96 to 1.37)
≥37	688/36 215	6573/397 469	1.08 (1.00 to 1.16)	0.95 (0.92 to 0.97)	0.13 (0.05 to 0.22)	1.14 (1.05 to 1.23)	1.08 (1.00 to 1.17)
Infant death by 1 y	13/360	≤5g/150	2.12 (0.97 to 3.27)	1.02 (−0.13 to 2.17)	1.10 (−0.53 to 2.73)	2.00 (0.56 to 7.11)	2.16 (0.58 to 7.99)

Abbreviation: HR, hazard ratio.

^aAdditional analysis 2: acute myocardial infarction, coronary artery revascularization, or acute stroke, evaluating mothers whose infant had a multiorgan major congenital anomaly; additional analysis 3: stratified by duration of follow-up, era of the index birth, preterm birth, and infant death within 1 year.

^bAdjusted for maternal demographics (marital status, immigration status), socioeconomic status (income quartile, educational level), previous maternal health (diabetes, modified Charlson Comorbidity Index score, chronic hypertension, history of alcohol-related disease, and depression), previous spontaneous abortion, and pregnancy complications.

^cFollow-up time begins at 1 year after the birth of the child.

^dAdditional covariate adjusted for in 1994-2003 includes maternal smoking history. Without this additional covariate, the adjusted HR is 1.18 (95% CI, 0.98-1.42).

^eAdditional covariates adjusted for in 2004-2013 include maternal smoking history and body mass index. Without these additional covariates, the adjusted HR is 1.38 (95% CI, 0.94-2.04).

^fExcludes mothers of infants with unknown gestational age.

^gPrecise number supressed owing to small cell size.