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The impact of MPO on the endothelium. Classically, MPO produces HOCl near the neutrophil-endothelial interface. Apart from the catalytic activity, MPO can also recruit and activate neutrophils. This novel paper demonstrates a physical interaction between MPO and heparan sulfate, leading to glycocalyx collapse. After transcytosis into the subendothelial space, MPO can also target extracellular matrix proteins and reduce NO bioavailability.
