Table 2. Cox Proportional Hazards Regression Models for the Risk of Chronic Low-grade Inflammation on the Incidence of Dementia, Alzheimer Disease, and Mortality.

CRP Cutoff Levela	No. (%)	Modelb	Alzheimer Disease		Dementia		Mortality
			HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
All Participants (N = 2656 [100.0%])
8 mg/L	201 (7.6)	1	1.22 (0.71-2.10)	.47	1.33 (0.82-2.15)	.25	1.78 (1.42-2.23)	<.001
With ApoE4		2	2.64 (0.89-7.80)	.08	2.44 (0.92-6.45)	.07	0.81 (0.43-1.53)	.52
9 mg/L	160 (6.0)	1	1.43 (0.80-2.55)	.22	1.59 (0.96-2.64)	.07	1.88 (1.47-2.41)	<.001
With ApoE4		2	3.47 (1.10-10.94)	.03	2.98 (1.08-8.27)	.04	0.84 (0.41-1.74)	.65
10 mg/L	122 (4.6)	1	1.39 (0.73-2.66)	.32	1.66 (0.96-2.89)	.07	1.79 (1.36-2.35)	<.001
With ApoE4		2	2.76 (0.74-10.30)	.13	2.46 (0.87-7.71)	.12	0.77 (0.32-1.83)	.55
Individuals Without CVD (n = 2334 [87.9%])
8 mg/L	158 (6.8)	1	1.23 (0.64-2.37)	.54	1.33 (0.75-2.37)	.33	1.71 (1.28-2.27)	<.001
With ApoE4		2	6.63 (1.80-24.5)	.005	4.14 (1.28-13.44)	.02	0.80 (0.31-2.07)	.65
9 mg/L	125 (5.4)	1	1.42 (0.72-2.83)	.31	1.60 (0.88-2.92)	.12	1.86 (1.36-2.54)	<.001
With ApoE4		2	6.89 (1.74-27.30)	.006	4.07 (1.22-13.59)	.02	0.88 (0.34-2.29)	.80
10 mg/L	95 (4.1)	1	1.21 (0.53-2.78)	.65	1.56 (0.79-3.09)	.20	1.78 (1.24-2.54)	.002
With ApoE4		2	6.82 (1.31-35.6)	.02	3.61 (0.86-15.16)	.08	0.99 (0.30-3.30)	.98

Abbreviations: CRP, C-reactive protein; CVD, cardiovascular diseases; HR, hazard ratio.

^aThe CRP levels greater than or equal to a given cutoff at least in 2 measurements to define chronic low-grade inflammation.

^bModel 1: HR of chronic low-grade inflammation after adjusting for age, sex, educational level, ApoE, and CVD. Model 2: HR of the interaction effects between chronic low-grade inflammation and ApoE4, adjusting for all covariates in model 1.