Table 3A. Log rank test for survival.
| H3K27 Mutant | H3K27me3- | H3K27Ac | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | Medium | High | |||||||||
| n | # of deaths | p-value | n | # of deaths | p-value | n | # of deaths | p-value | |||
| Total | 33 | 21 | 0.283 | 27 | 15 | 0.798 | 30 | 3 | 3 | 14 | 0.294 |
| Anatomical location | |||||||||||
| Midline | 23 | 17 | 0.551 | 22 | 15 | 0.060 | 19 | 3 | 3 | 13 | 0.197 |
| Brainstem | 9 | 9 | n/a | 8 | 6 | 0.371 | 6 | 1 | 1 | 4 | 0.556 |
| Thalamus | 14 | 8 | 0.631 | 14 | 9 | 0.762 | 13 | 2 | 2 | 9 | 0.212 |
| Non-midline | 6 | 2 | 0.198 | 5 | 0 | n/a | 1 | n/a | n/a | n/a | n/a |
| Cerebellar hemisphere | 1 | 1 | n/a | 1 | 0 | n/a | n/a | n/a | n/a | n/a | n/a |
| Cerebral hemisphere | 5 | 1 | 0.156 | 4 | 0 | n/a | 1 | n/a | n/a | 1 | n/a |
| Gender | |||||||||||
| Female | 20 | 11 | 0.521 | 13 | 7 | 0.636 | 10 | 1 | n/a | 9 | 0.963 |
| Male | 13 | 9 | 0.346 | 14 | 8 | 0.729 | 10 | 1 | 3 | 5 | 0.187 |
| Age | |||||||||||
| <5 years | 9 | 5 | 0.035* | 7 | 4 | 0.446 | 7 | n/a | 1 | 6 | 0.177 |
| 5-10 years | 6 | 6 | 0.060 | 6 | 4 | 0.761 | 5 | 2 | 1 | 2 | 0.864 |
| >10 years | 14 | 8 | 0.598 | 14 | 7 | 0.295 | 8 | 1 | 1 | 6 | 0.253 |
| WHO-Grade | |||||||||||
| I | 10 | 0 | n/a | 1 | 0 | n/a | 3 | n/a | n/a | 1 | n/a |
| II | 3 | 2 | 0.157 | 3 | 2 | 0.225 | 2 | n/a | 1 | 1 | 0.317 |
| III | 10 | 6 | 0.656 | 10 | 5 | 0.523 | 6 | 1 | 1 | 4 | 0.276 |
| IV | 15 | 11 | 0.321 | 13 | 8 | 0.972 | 11 | 2 | 1 | 8 | 0.857 |
n = 63, total deaths = 33 (52.38%).