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. 2018 Dec 14;9(98):37173–37184. doi: 10.18632/oncotarget.26444

Figure 1.

Figure 1

(A) Activity of TP-0903 (tartrate salt) vs. TP-0903 (free base) on CLL B-cell apoptosis: CLL B-cells from previously untreated patient (n=8) were treated with increasing doses (0.05-0.50 μM) of Axl inhibitor TP-0903 (tartrate salt) or TP-0903 (free base) for 24 hours. Apoptosis induction was determined and results are presented as mean values with SD. The p-value was done using a paired t-test. (B) Comparison of bioavailability of TP-0903 (tartrate salt) with TP-0903 (free base): The PK study was performed in Sprague-Dawley male fasted rats (n=3) after a single 20 mg/kg dose of TP-0903 (free base or tartrate salt) by oral gavage. PK parameters were calculated by Phoenix WinNonlin using a standard non-compartmental model. Details provided in a table by the figure. Bioavailability was determined for each form of TP-0903 by comparing the AUC to a control group of rats administered TP-0903 intravenously.