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. 2018 Dec 14;9(98):37097–37111. doi: 10.18632/oncotarget.26365

Figure 5. TAGLN2 regulates invasion of IDH1/2 WT GBM cells in vitro.

Figure 5

Since TAGLN2 has been shown to play a role in invasion and metastases of other cancer types, the invasive ability of (A) GBM30 neurospheres with stable shRNA-mediated knock-down of TAGLN2 were compared to their respective scrambled shRNA control. GBM30 cells showed a decrease in average number of cells invading through the matrix after knock-down of TAGLN2 compared to control. In contrast, (B) GBM30 neurospheres and (C) U87 MG glioma cells with stable overexpression of TAGLN2 showed an increase in average number of cells invading through the matrix compared to vector control. Experiments were performed three times with triplicate invasion assays. *, statistically significant difference in invading cells (p<0.05). Photographs are representative images at 40x and 100x magnification.