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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Cell Stem Cell. 2018 Nov 15;23(6):869–881.e8. doi: 10.1016/j.stem.2018.10.010

Figure 5: Cell specific expression of disease-relevant genes in adult kidney compared to organoids.

Figure 5:

Cell specific expression of genes reported in CKD related GWAS (A), hypertension related GWAS (B), and plasma metabolite levels related GWAS (C) in adult kidney. Each gene reported in a kidney disease related GWAS was assigned to the adult kidney cell type in which it was found to be differentially expressed (likelihood ratio test). Heatmap was used to visualize the z-score normalized average gene expression of the candidate genes for each cell cluster. (D-F) Disease relevant genes identified in (A-C) for which cell-specific expression could also be detected in organoid cell types. Results from both protocols and both cell sources were pooled for the analysis.