Figure 2. KLHL5 knockdown sensitizes to anticancer drugs.

(A) Viability change for paired library screening of anticancer compounds. The difference reflects the normalized observed viability minus the expected viability. Data represents the average distance between the means of two replicates. (B) Drug sensitivity shifts with KLHL5 knockdown by ratio and difference. Observations represented with a round symbol are distinguished for those ratios of greater 1.3 or less than 0.7 (common thresholds for synergistic or antagonistic relationships). Plus symbols are used for relationships where little change in sensitivity was observed. Color is used for drugs targetting cell cycle (red) or PI3K/Akt/mTOR pathways (blue). Data represents the mean of two replicates.