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. 2019 Jan 8;16(1):e1002722. doi: 10.1371/journal.pmed.1002722

Table 3. Lung function development in relation to asthma debut, duration, and remission.

Measure N Difference (95% CI) p-Value
z-Score before diagnosis relative to children never developing asthma
FEVz before diagnosis# 93 −0.29 (−0.49; −0.09) 0.004
MMEFz before diagnosis# 93 −0.40 (−0.60; −0.20) <0.001
sRawz before diagnosis# 32 +0.33 (+0.10; +0.57) 0.006
PDz before diagnosis# 87 −0.35 (−0.59; −0.12) 0.003
Change in z-score per year duration of asthma
FEVz development# 92 +0.02 (−0.02; +0.07) 0.36
MMEFz development# 92 −0.01 (−0.05; +0.03) 0.68
sRawz development# 89 −0.02 (−0.06; +0.03) 0.43
PDz development# 87 −0.04 (−0.10; +0.03) 0.27
Change in z-score per year after remission of asthma
FEVz development# 54 +0.02 (−0.03; +0.06) 0.44
MMEFz development# 54 −0.00 (−0.04; +0.04) 0.98
sRawz development# 51 +0.01 (−0.03; +0.06) 0.54
PDz development# 48 +0.00 (−0.07; +0.08) 0.92

Significant p-values in bold.

#Mixed models.

FEV, forced expiratory volume; MMEF, maximal mid-expiratory flow; PD, provocative dose of methacholine; sRaw, specific airway resistance.