Table 4. Cross psychiatric disorders meta-analysis of 63 predicted functional SNPs.
| SNPs | Allele | Function | Datasets | I | P-val | OR |
|---|---|---|---|---|---|---|
| rs17480644 | A/G | TFBS | ADHD, AN, BD, OCD, SCZ | 8 | 0.083 | 1.039 |
| rs1260124 | A/T | TFBS | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.635 | 0.996 |
| rs35796336 | T/C | TFBS | AN, ASD, BD, OCD, SCZ | 0 | 0.049 | 1.027 |
| rs10277276 | T/C | TFBS | BD, OCD, SCZ | 0 | 0.764 | 0.992 |
| rs34712024 | A/G | TFBS | ADHD, AN, BD, OCD, SCZ | 32 | 0.626 | 1.012 |
| rs2462603 | A/G | TFBS | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.303 | 0.993 |
| rs1639484 | A/T | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.376 | 1.005 |
| rs12703814 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.965 | 0.999 |
| rs1639447 | A/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.376 | 0.990 |
| rs769344 | C/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.778 | 0.996 |
| rs10280967 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.639 | 0.996 |
| rs10243142 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.738 | 1.002 |
| rs12535047 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 0 | 0.327 | 0.993 |
| rs347201 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.089 | 1.011 |
| rs13234249 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 2 | 0.101 | 1.011 |
| rs12666908 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.914 | 0.999 |
| rs11972428 | T/G | SeqCons | ADHD, AN, BD, OCD, SCZ | 0 | 0.672 | 1.012 |
| rs34222835 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 4 | 0.045 | 0.979 |
| rs10261412 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 52 | 0.808 | 0.995 |
| rs1826843 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 20 | 0.153 | 0.990 |
| rs17170356 | A/G | SeqCons | ADHD, AN, BD, OCD, SCZ | 0 | 0.137 | 0.972 |
| rs4726831 | A/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 18 | 0.294 | 0.990 |
| rs10279700 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 26 | 0.857 | 0.998 |
| rs35701811 | A/G | SeqCons | ADHD, AN, BD, OCD, SCZ | 0 | 0.899 | 0.998 |
| rs899617 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.026 | 1.014 |
| rs747140 | C/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.025 | 1.014 |
| rs7798078 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 0 | 0.091 | 1.011 |
| rs34592169 | A/G | Splicing | ADHD, AN, ASD, BD, OCD, SCZ | 15 | 0.067 | 1.014 |
| rs6970064 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 7 | 0.462 | 1.004 |
| rs17170640 | A/G | SeqCons | ADHD, AN, BD, OCD, SCZ | 0 | 0.018 | 1.041 |
| rs16883690 | A/C | SeqCons | BD, SCZ | 66 | 0.673 | 1.066 |
| rs7797724 | T/C | SeqCons | BD, SCZ | 0 | 0.047 | 1.592 |
| rs851659 | A/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 9 | 0.349 | 0.993 |
| rs35815165 | -/AA | SeqCons | ADHD, AN | 0 | 0.831 | 1.002 |
| rs13247212 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.797 | 0.996 |
| rs1177007 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 0 | 0.238 | 1.008 |
| rs12154883 | T/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.645 | 1.006 |
| rs13438769 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 0 | 0.057 | 1.018 |
| rs2707580 | T/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.146 | 0.990 |
| rs2707581 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.156 | 0.990 |
| rs2141955 | A/G | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.032 | 1.015 |
| rs34347668 | A/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ | 0 | 0.973 | 1.000 |
| rs4725756 | A/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 0 | 0.015 | 0.984 |
| rs2888540 | T/C | SeqCons | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 0 | 0.023 | 1.014 |
| rs17170789 | A/T | SeqCons | ADHD, AN, BD, OCD, SCZ | 0 | 0.566 | 1.010 |
| rs17170801 | A/C | SeqCons | ADHD, AN, BD, OCD, SCZ | 0 | 0.643 | 0.989 |
| rs10279343 | T/C | SeqCons | ADHD, AN, BD, OCD, SCZ | 1 | 0.568 | 1.014 |
| rs1122622 | A/C | SeqCons | AN, BD, OCD, SCZ | 66 | 0.745 | 1.026 |
| rs5888312 | -/A | SeqCons | ADHD, AN | 70 | 0.744 | 1.010 |
| rs9648691 | A/G | SeqCons, Splicing | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 64 | 0.806 | 1.002 |
| rs987456 | A/C | miRNA | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 29 | 0.570 | 1.004 |
| rs2717809 | C/G | miRNA | AN, BD, OCD, SCZ | 0 | 0.746 | 0.989 |
| rs2530312 | A/G | miRNA | ADHD, AN, ASD, BD, OCD, SCZ | 70 | 0.485 | 0.990 |
| rs3194 | A/C | miRNA | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 68 | 0.797 | 1.003 |
| rs10243309 | C/T | miRNA | AN, MDD | 15 | 0.125 | 1.149 |
| rs17170999 | A/G | miRNA | AN, BD, OCD, SCZ, MDD | 0 | 0.026 | 0.917 |
| rs2530311 | A/G | miRNA | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 66 | 0.975 | 0.999 |
| rs17171000 | T/C | miRNA | ADHD, AN, BD, OCD, SCZ, MDD | 0 | 0.583 | 0.988 |
| rs10251347 | C/G | miRNA | ADHD, AN, BD, OCD, SCZ, MDD | 0 | 0.428 | 0.986 |
| rs2717829 | C/G | miRNA | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 50 | 0.820 | 0.997 |
| rs10280038 | A/G | miRNA | AN, BD, OCD, SCZ, MDD | 0 | 0.031 | 1.087 |
| rs2530310 | T/C | miRNA | ADHD, AN, ASD, BD, OCD, SCZ, MDD | 67 | 0.666 | 0.994 |
| rs17171006 | T/C | miRNA | ADHD, AN, BD, OCD, SCZ | 0 | 0.493 | 0.985 |
For each predicted functional SNP, the alternative alleles and predicted function are listed. P-values (P-val) were calculated considering fixed-model effect, except SNPs with evidence of heterogeneity (I>50) where odds ratios (OR) were considered under random-effects. Nominally significant associations are indicated in bold (P-values<0.05), but none exceed correction for multiple testing (P<7.9E-04). Abbreviations: TFBS, transcription factor binding site; SeqCons, sequence conserved nucleotide across species; miRNA, predicted miRNA binding site; Splicing, exonic splicing enhancer (ESE).