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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: Curr Allergy Asthma Rep. 2018 Feb 22;18(3):16. doi: 10.1007/s11882-018-0773-y

Figure 1. Overview schematic of the proposed relationship of inhalant organic dust exposures induction of bone loss.

Figure 1.

Inhalation of complex agriculture organic dust induces an airway inflammatory response that leads to a systemic response and bone deterioration findings. The “+” sign = positive activator of the pathway. The “-” sign = negative influence or blockade of the pathway. M-CSF = macrophage colony-stimulating factor. M-CSFr = macrophage colony-stimulating factor receptor. RANK = receptor activator of nuclear factor kappa-β. RANKL = receptor activator of nuclear factor kappa-β ligand. TLR = Toll-like receptor. MyD88 = myeloid differentiation factor 88. IL-6 = Interleukin-6.