Fig. 1.

Schematic of the molecular targets of resveratrol related to metabolism. Resveratrol potentially activates multiple targets, converging on pathways that lead to mitochondrial biogenesis and fatty acid oxidation. In the gut (right), where resveratrol concentrations are likely higher than plasma in animals, resveratrol leads to secretion of GLP-1 and an improvement in glucose tolerance. Green and blue arrows represent activation and red bars represent inhibition