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. Author manuscript; available in PMC: 2019 Jan 8.
Published in final edited form as: Science. 2013 Aug 9;341(6146):660–664. doi: 10.1126/science.1237150

Fig. 4. Effects of DNA repair machinery on DSB pairing and translocation formation.

Fig. 4.

(A) The percentage of NIH3T3duo cells with paired LacO-TetO arrays was assessed after ISceI or ISceID44A expression for 24 hours in the presence of the indicated inhibitors. Values represent means ± SD from at least four independent experiments (Student t test or χ2 test, *P < 0.05). (B) Real-time PCR on DNA from cells transfected with ISceI for 24 hours in the presence of the indicated inhibitors. The untreated sample was used as a control. Values represent means ± SD from at least four independent experiments (Student t test, *P < 0.05, ***P < 0.0001). (C) Percentage of cells with paired LacO-TetO arrays in cells treated with the indicated siRNAs or shRNAs as in (A) (Student t test, *P < 0.05). Values represent means ± SD from at least two independent experiments. (D) Real-time PCR of NIH3T3- duo cells treated with the indicated siRNAs performed as in (B) (Student t test, *P < 0.05).