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During cholangiocyte damage, cholangiocytes and/or HPCs proliferate to compensate biliary cell population and functions. Hepatocytes transdifferentiate into cholangiocytes and/or biliary-like cells that have different gene expression profiles. During hepatocyte damage, cholangiocytes start proliferation and transdifferentiate into hepatocytes via HPCs. The types of DR and the origin of active cells vary depending on liver injuries or experimental conditions.
