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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Hepatology. 2018 Dec 17;69(1):343–358. doi: 10.1002/hep.30131

Figure 1.

Figure 1.

Effects of PXR activation on liver enlargement in wild-type (WT) and Pxr-null mice. (A) WT or Pxr-null mice were treated with vehicle (corn oil) or 100 mg/kg/d PCN for 5 days. (B) Liver-to-body-weight ratios (n = 6). (C) Representative gross pictures of WT or Pxr-null mice. (D) Histopathological analysis of representative mouse liver samples following H&E staining. (E) IHC staining of central vein areas for CTNNB1 (Membrane CTNNB1 staining was performed to describe the cell size). (F) Quantification of the cell size (n = 3). The data are expressed as the means ± SD. *P < 0.05 and **P < 0.01 compared with the vehicle group.