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PXR activation results in hepatocyte proliferation and hybrid periportal hepatocyte (hepatic progenitor-like cell) reprograming. (A-B) IHC staining of portal vein areas for KI6 and SOX9 in WT or Pxr-null mice. (C-D) IHC staining of portal vein areas for KI67 and SOX9 in hPXR mice. (E) HNF4a and PH3 double staining of portal vein areas or central vein areas in PCN-treated mice. (F) SOX9 and KI67 double staining of portal vein areas or central vein areas in PCN-treated mice.
