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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Behav Brain Res. 2018 Dec 12;360:262–269. doi: 10.1016/j.bbr.2018.12.027

Figure 7. The effect of bupropion on the locomotor activity in various nAChRs subtypes.

Figure 7.

Mice were placed into photocell activity cages for 10 min after 30 min s.c. administration of bupropion (3 and 10 mg/kg) in α4 KO (A), α6 KO (B) and WT mice (C). The C57BL/6J mice (C) were injected s.c. DHβE (3 mg/kg) or vehicle (saline) 20 min before bupropion treatment. After 30 min bupropion (3 and 10 mg/kg, s.c.) or vehicle (saline) injection, mice were tested in activity cages. Results were expressed as the mean ± SEM as the number of photocell interruptions of α4 6 (WT) and 6 (KO); α6 8 (WT) and 8 (KO); . * p < 0.05, significantly different from vehicle group in WT animals or in vehicle pretreated group C57BL/6J mice; + p < 0.05, significantly different from vehicle group in KO animals or in DHβE pretreated group. Bup: bupropion