Table 3.
Family history of melanoma and risk of melanoma by Breslow thickness
| Person- years |
Melanoma with Breslow ≤1mm |
Melanoma with Breslow >1mm |
P for heterogeneity |
|||||
|---|---|---|---|---|---|---|---|---|
| n | Age-adjusted HR (95% CI) |
MV-adjusted HRa (95% CI) |
n | Age-adjusted HR (95% CI) |
MV-adjusted HRa (95% CI) |
|||
| Nurses’ Health Study (82–12) | ||||||||
| No family history | 2208276 | 496 | 1.00 | 1.00 | 172 | 1.00 | 1.00 | |
| With family history | 125129 | 72 | 2.21 (1.72, 2.83) | 1.93 (1.50, 2.48) | 30 | 2.60 (1.76, 3.85) | 2.42 (1.63, 3.58) | 0.34 |
| Nurses’ Health Study II (89–11) | ||||||||
| No family history | 1744100 | 344 | 1.00 | 1.00 | 44 | 1.00 | 1.00 | |
| With family history | 184278 | 57 | 1.43 (1.08–1.91) | 1.30 (0.97–1.73) | 17 | 3.45 (1.94, 6.14) | 3.10 (1.73, 5.54) | 0.009 |
|
Health Professionals Follow-up
Study (90–12) |
||||||||
| No family history | 470142 | 200 | 1.00 | 1.00 | 72 | 1.00 | 1.00 | |
| With family history | 24506 | 18 | 1.71 (1.05–2.77) | 1.57 (0.85–2.88) | 10 | 2.62 (1.35–5.09) | 2.32 (1.19–4.52) | 0.33 |
| Meta-analysis | ||||||||
| No family history | 4422518 | 1040 | - | 1.00 | 288 | - | 1.00 | |
| With family history | 333913 | 147 | - | 1.59 (1.21–2.08) | 57 | - | 2.55 (1.91, 3.42) | 0.02 |
CI: confidence interval; HR: hazard ratio
a
Stratifying by age and questionnaire cycle, and adjusting for BMI (<25, 25–29.9, or ≥30 kg/m2), smoking (never, past, or current smokers), alcohol intake (0, 0–4.9, 5–9.9, or ≥10 g/d), citrus consumption (<2 times/wk, ≥2-≤4 times/wk, >4 times/wk-<1 time/d, or ≥1 time/d), physical examination (yes or no), erythemal UV radiation (in quintiles), personal history of keratinocyte carcinoma (yes or no), and other host characteristics, including hair color, nevi count, tanning ability (NHS only), burning susceptibility, and number of sunburns.