Table 1:

Characteristics of the lung cancer cases and controls

	Cases	Controls		P1	P2
Demographics	(n=262)	Negative Scan N=418	Positive Scan N=110
Age
Median (IQR) in years	64 (60–68)	64 (59–68)	64.5 (61–68)	0.50	0.57
Gender
Male	159	263	59	0.56	0.21
Female	103	155	51
Race
White	488	384	104
Black or African-American	22	19	3
Asian	6	6	0	0.36	0.27
American Indian or Alaskan Native	1	1	0
Native Hawaiian or other Pacific Islander	3	3
More than one race	5	4	1
Missing	3	1	2
Smoking Status at Randomization
Former	124	182	49	0.33	0.62
Current	138	236	61
Pack-years of Smoking
Median (IQR) in years	57 (43–76.5)	51 (43–76)	50 (42.4–69)	0.22	0.05
BMI
Median (IQR) in years	26.4 (24.0–29.2)	26.6 (24.4–30.1)	26.2 (22.9–30.13)	0.06	0.77
Family History of Lung Cancer
No	192	304	82	0.71	0.61
Yes	57	84	21
Tumor Stage
IA	160
IB	25
IIA	5
IIIA	15
IIIB	23
IV	10
Unable to assess	7
Tumor Histology
Large cell carcinoma, NOS	6
Large cell neuroendocrine carcinoma	2
Tumorlet, NOS	14
Oat cell carcinoma	1
Small cell carcinoma	3
Non-small cell carcinoma	21
Squamous cell carcinoma	52
Squamous cell carcinoma, keratinizing, NOS	6
Squamous cell carcinoma, large cell, non-keratinizing	1
Adenocarcinoma	87
Carcinoid	2
Bronchiolo-alveolar adenocarcinoma	40
Bronchiolo-alveolar adenocarcinoma, non-mucinous	3
Bronchiolo-alveolar adenocarcinoma, mixed	5
Adenocarcinoma with mixed subtypes	3
Papillary adenoma	6
Signet ring cell carcinoma	5
Acinar cell adenoma	3
Mixed squamous cell and glandular papilloma	4
Adenocarcinoma with squamous metaplasia	1

¹P denotes differences between controls with a negative LDCT scan and lung cancer patients

²P denotes differences between controls with a positive LDCT scan and lung cancer patients