Table 2:

Relationship between inflammation proteins with lung cancer diagnosis among individuals with a negative LDCT screen

		Univariable		Multivariable
	Control/Case	Participants with a negative LDCT scan		Participants with a negative LDCT scan
		OR (95% C.I.)	P	OR (95% C.I.)	P*
IL-6
<25th Percentile	103/42	Reference		Reference
25th – 50th Percentile	103/58	1.38 (0.85–2.24)	0.19	1.48 (0.87–2.53)	0.15
50th – 75th Percentile	103/73	1.74 (1.09–2.77)	0.02	1.88 (1.11–3.21)	0.02
>75th Percentile	103/83	2.00 (1.26–3.16)	0.003	2.82 (1.64–4.86)	<0.001
Trend		1.40 (1.18–1.66)	0.002	1.40 (1.18–1.66)	<0.001
<Median	206/100	Reference		Reference
>Median	205/156	1.57 (1.14–2.15)	0.005	1.84 (1.26–2.68)	0.001
IL-8
<25th Percentile	105/50	Reference		Reference
25th – 50th Percentile	104/69	1.40 (0.88–2.19)	0.15	1.57 (0.95–2.60)	0.08
50th – 75th Percentile	105/52	1.04 (0.65–1.67)	0.87	1.08 (0.63–1.86)	0.77
>75th Percentile	104/91	1.84 (1.18–2.85)	0.007	2.25 (1.37–3.71)	0.001
Trend		1.18 (1.02–1.35)	0.02	1.25 (1.06–1.46)	0.006
<Median	209/119	Reference		Reference
>Median	209/143	1.20 (0.88–1.63)	0.25	1.30 (0.90–1.86)	0.16
CRP
<25th Percentile	105/50	Reference		Reference
25th – 50th Percentile	104/69	1.57 (0.98–2.52)	0.06	1.65 (0.96–2.83)	0.07
50th – 75th Percentile	105/52	1.81 (1.14–2.87)	0.01	2.18 (1.28–3.71)	0.004
>75th Percentile	104/91	1.76 (1.11–2.80)	0.02	2.46 (1.43–4.23)	0.001
Trend		1.19 (1.03–1.37)	0.02	1.33 (1.13–1.58)	0.001
<Median	209/119	Reference		Reference
>Median	209/143	1.39 (1.02–1.90)	0.04	1.73 (1.20–2.49)	0.003
IFN-g
<25th Percentile	104/50	Reference		Reference
25th – 50th Percentile	103/57	1.15 (0.72–1.84)	0.56	1.11 (0.65–1.87)	0.72
50th – 75th Percentile	104/64	1.28 (0.81–2.03)	0.29	1.28 (0.76–2.13)	0.35
>75th Percentile	103/91	1.84 (1.18–2.85)	0.007	1.89 (1.16–3.09)	0.01
Trend		1.22 (1.06–1.40)	0.005	1.24 (1.06–1.45)	0.007
<Median	207/107	Reference		Reference
>Median	207/155	1.45 (1.06–1.98)	0.02	1.50 (1.06–2.14)	0.02
IL-12/IL-23p40
<25th Percentile	105/50	Reference		Reference
25th – 50th Percentile	104/65	1.31 (0.83–2.07)	0.24	1.25 (0.73–2.12)	0.42
50th – 75th Percentile	105/62	1.24 (0.78–1.97)	0.36	1.59 (0.93–2.72)	0.09
>75th Percentile	104/85	1.72 (1.10–2.67)	0.02	2.49 (1.46–4.23)	0.001
Trend		1.17 (1.02–1.35)	0.03	1.36 (1.15–1.61)	0.001
<Median	209/115	Reference		Reference
>Median	209/147	1.27 (0.94–1.74)	0.12	1.77 (1.22–2.57)	0.002

^*P adjusted for age, gender, smoking status, pack-years of smoking, race, BMI, history of COPD, childhood asthma, adulthood asthma, asbestosis, chronic bronchitis, bronchiectasis, emphysema, fibrosis of the lung, pneumonia, sarcoidosis, silicosis, tuberculosis, diabetes, family history of lung cancer