Table 1.
MICs (µg/ml) for six isolates of M. pachydermatis obtained from the toy Poddle dog, a reference strain and 10 isolates of the yeast coming from dogs never subjected to antifungal therapies.
|
ITZ |
KTZ |
MCZ | TER | CTZ | PSZ | FCZ | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Provenance | MiB | E-test | MiB | E-test | MiB | MiB | MiB | E-test | E-test |
| CBS 15214a | skin (abdomen) | 0.5 | 0.75 | 2 | 0.75 | 16 | 1 | 32 | 1.5 | > 256 |
| CBS 15215a | skin (dorsum) | 1 | 0.75 | 2 | 1 | 16 | 1 | 16 | 1.5 | 128 |
| CBS 15216a | right ear | 8 | > 32 | 16 | 1.5 | > 32 | 4 | 16 | 4 | > 256 |
| CBS 15208b | right ear | 1 | 0.75 | 4 | 1 | 16 | 1 | 32 | 2 | 128 |
| CBS 15212b | skin (neck) | 1 | 0.5 | 4 | 0.75 | 16 | 2 | 32 | 1.5 | > 256 |
| CBS 15211b | skin (left thigh) | 1 | 0.75 | 4 | 0.5 | 16 | 2 | 32 | 1.5 | > 256 |
| CBS 1879 | reference strain | 0.03 | 0.125 | 0.25 | 0.125 | 2 | 0.5 | 4 | 0.25 | 12 |
| / | dogs never subjected to antifungal therapiesc | 0.016–0.06 | 0.023–0.094 | 0.03–0.125 | 0.19–0.125 | 1–4 | / | 1–16 | / | / |
a,b = obtained from the toy Poddle dog, a) on day + 940; b) at the occasion of a follow up visit (day + 1350); c = for these isolates (n = 10) the range of MICs obtained is provided.
Number = the accession number assigned by the fungal collection of the Westerdijk Institute (formerly the Fungal Biodiversity Center – CBS) of Utrecht. MiB = microplate broth-dilution method. ITZ = Itraconazole; MCZ = Miconazole; TER = Terbinafine; KTZ = Ketoconazole; CTZ = Clotrimazole; PSZ = Posaconazole; FCZ = Fluconazole.