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. 2018 Dec 1;14:192–203. doi: 10.1016/j.omtn.2018.11.014

Figure 1.

Figure 1

miR-103 Promotes Inflammation in Mouse Adipose

(A) Heatmaps of miRNAs in adipose tissue of normal or DIO mice (GEO: GSE85101). (B) Relative levels of the most upregulated or downregulated miRNA in DIO mouse adipose tissue. (C) The relative level of miR-103 in adipose tissue of ND or HFD mice or ND mice injected with PBS or LPS. (D) Relative levels of MCP-1, NLRP3, IL-1β, and ASC mRNAs in HFD mouse adipose after treatment with Ad-miR103 or Ad-GFP. (E) Relative levels of MCP-1, NLRP3, IL-1β, and ASC mRNAs in Ad-miR103/Ad-GFP- and LPS-treated ND mouse adipose. (F) The relative miR-103 level in adipocytes after treatment with PBS or LPS. (G) Relative IL-6, NLRP3, Caspase 1, and IL-1β protein levels in adipocytes after transfection with miR-103 mimics, inhibitor, or NC and treatment with LPS. Error bar, SE. All data are represented as the mean ± SEM (*p < 0.05 and **p < 0.01; n ≥ 3).