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. 2019 Jan 8;10(1):14. doi: 10.1038/s41419-018-1243-0

Fig. 7. Phosphorylation of p65/RelA at S536 is essential for CXCL10 induction and displays pro-fibrogenic effects in Lx2 cells.

Fig. 7

a CXCL10 expression in cells transfected with a control plasmid (pC) or a plasmid expressing the constitutive active form of IKKβ (pIKKb-ON) and mock treated or treated with 30 µM DHA for 24 h. b–d Lx2 cells were transfected with a control plasmid (pC), a plasmid expressing wild-type p65/RelA (pWT) or a mutant S536A that cannot be phosphorylated (pA). At 24 h, the cells were mock treated or treated with 30 µM DHA for 24 h. CXCL10 (b) and COL1A1 and αSMA expression (d). Data are means ± SD from three experiments. p65/RelA and p-p65/RelA(S536) protein in total extracts (c)