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. 2019 Jan 8;10:78. doi: 10.1038/s41467-018-07962-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Model for MPER accessibility within native Env complexes based on Cryo-EM reconstructions¹⁵. Top: Contours derived from detergent-solubilized Env trimers, without (left) or with 10E8 bound (right), have been docked into a viral lipid bilayer. A putative transition between these two states would result in exposure of the MPER helix in native Env (green). Bottom: cartoons to designate in the previous models the different trimer components, and positions of the neutralizing epitopes for bnAbs used in this study PGT145 (V1/V2), VRC01 and b12 (CD4bs); and 10E8/4E10 (MPER)