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. 2019 Jan 8;10:77. doi: 10.1038/s41467-018-08035-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Genetic ablation or silencing of Zfp36l1 abrogates OA pathogenesis in mice. a, b WT (Zfp36l1^+/+) and Zfp36l1^+/− mice were subjected to sham operation (n = 7 mice per group) or DMM surgery (n = 12 mice per group). Representative Safranin-O staining images (a) and scoring of OARSI grade, osteophyte maturity, and subchondral bone plate thickness (b). c, d Sham-operated (n = 6 mice per group) or DMM-operated (n = 12 mice per group) WT mice were IA injected with Ad-shC as a control or Ad-shZFP36L1 to knock down ZFP36L1 in the joint tissues. Representative Safranin-O staining images of joint sections (c) and scoring of OARSI grade, osteophyte maturity, and subchondral bone plate thickness (d). Means ± 95% CI with Mann–Whitney U test for OARSI grade and osteophyte maturity. Means ± s.e.m. with two-tailed t-test for SBP thickness. SBP subchondral bone plate. Scale bar: 50 μm