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. 2019 Jan 8;10(1):19. doi: 10.1038/s41419-018-1261-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative images of LC3 staining by measuring fluorescence intensity of HDFs in different groups of cells infected with RFP-GFP-LC3 adenovirus for 24 h by fluorescence microscopy. b Quantitation of punctate structures per cell, based on the number of punctate structures in GFP-RFP-LC3-positive cells. c Cell viability in response to AZD1480. d Expression levels of JAK2, phospho-JAK2, STAT3, phospho-STAT3, AKT, and phospho-AKT measured by Western blot analysis in response to CSF2 depletion or CSF2 oversupply. e, h Relative protein expression levels of AKT and phospho-AKT in response to CSF2 depletion and CSF2 oversupply. f, i Relative protein expression levels of JAK2 and phospho-JAK2 in response to CSF2 depletion and CSF2 oversupply. g, j Relative protein expression levels of STAT3 and phospho-STAT3 in response to CSF2 depletion and CSF2 oversupply. Results presented as means ± SD of three independent experiments (n = 3). *Compared with the UVB-treated group, P < 0.05

Fig. 4 — a Representative images of LC3 staining by measuring fluorescence intensity of HDFs in different groups of cells infected with RFP-GFP-LC3 adenovirus for 24 h by fluorescence microscopy. b Quantitation of punctate structures per cell, based on the number of punctate structures in GFP-RFP-LC3-positive cells. c Cell viability in response to AZD1480. d Expression levels of JAK2, phospho-JAK2, STAT3, phospho-STAT3, AKT, and phospho-AKT measured by Western blot analysis in response to CSF2 depletion or CSF2 oversupply. e, h Relative protein expression levels of AKT and phospho-AKT in response to CSF2 depletion and CSF2 oversupply. f, i Relative protein expression levels of JAK2 and phospho-JAK2 in response to CSF2 depletion and CSF2 oversupply. g, j Relative protein expression levels of STAT3 and phospho-STAT3 in response to CSF2 depletion and CSF2 oversupply. Results presented as means ± SD of three independent experiments (n = 3). *Compared with the UVB-treated group, P < 0.05