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. 2019 Jan 8;10(1):15. doi: 10.1038/s41419-018-1251-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Frequency of dCTLA-4⁺Tim-3⁺CD4⁺Tcells from normal pregnancy (NP) and patients diagnosed with recurrent spontaneous abortion (RSA). b Expression of ki67, CD127, and CD69 of dCTLA-4⁺Tim-3⁺CD4⁺T cells from NP and RSA. d–f Pro- and anti-inflammatory cytokines production and transcription factors expression by dCTLA-4⁺Tim-3⁺CD4⁺Tcells from NP and RSA. Data represented the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. NP normal pregnancy, n = 23; RSA recurrent spontaneous abortion, n = 26