TABLE 2.
Antibiotic resistance gene products enriched by strain origin (P < 0.01 and FDR q < 0.1) for B. cereus for origins with n ≥ 3a
| B. cereus ARG product | Antibiotic class or other |
% of strains from origin (n): |
FDR q | ||
|---|---|---|---|---|---|
| BE-ISS (8) | Soil (11) | Human (33) | |||
| Metallothiol transferase FosB 2 | Fosfomycin | 0.0 | 45.5 | 84.8 | 0.001 |
| UDP-4-amino-4-deoxy-l-arabinose–oxoglutarate aminotransferase | Polymyxin | 0.0 | 54.5 | 0.0 | 0.005 |
| Multidrug resistance protein EbrB | Multidrug | 100.0 | 27.3 | 57.6 | 0.045 |
| Beta-lactamase 3 | Penicillin | 0.0 | 63.6 | 18.2 | 0.077 |
| Cadmium resistance transcription regulatory protein CadC | Heavy metal* | 0.0 | 9.1 | 24.2 | 0.077 |
| Multidrug resistance protein Stp | Multidrug | 100.0 | 63.6 | 100.0 | 0.080 |
a
Percentage of strains from the respective origins encoding each function are listed. Gene products that were more frequently present in ISS strains than soil- and/or putatively commensal human-derived strains are displayed in bold. *, not an antibiotic class, though can be associated with antibiotic resistance.