TABLE 2.
MIC distributions for plazomicin against aminoglycoside-susceptible and aminoglycoside-nonsusceptible Enterobacteriaceae and Pseudomonas aeruginosa
| Organism (no. of isolates) and agenta |
No. of isolates (cumulative percentage of isolates) with the following plazomicin MIC (µg/ml): |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | >64 | |
| Escherichia coli | |||||||||||
| Amikacin S (3,087) | 21 (0.7) | 642 (21.5) | 1,731 (77.6) | 599 (97.0) | 78 (99.5) | 16 (100) | |||||
| Amikacin NS (7) | 1 (14.3) | 2 (42.9) | 3 (85.7) | 1 (100) | |||||||
| Gentamicin S (2,811) | 21 (0.7) | 596 (21.9) | 1,565 (77.6) | 540 (96.8) | 75 (99.5) | 14 (100) | |||||
| Gentamicin NS (283) | 46 (16.3) | 167 (75.3) | 61 (96.8) | 6 (98.9) | 2 (99.6) | 1 (100) | |||||
| Tobramycin S (2,839) | 21 (0.7) | 621 (22.6) | 1,579 (78.2) | 529 (96.9) | 75 (99.5) | 14 (100) | |||||
| Tobramycin NS (255) | 21 (8.2) | 153 (68.2) | 72 (96.5) | 6 (98.8) | 2 (99.6) | 1 (100) | |||||
| Klebsiella pneumoniae | |||||||||||
| Amikacin S (1,038) | 59 (5.7) | 807 (83.4) | 156 (98.5) | 13 (99.7) | 2 (99.9) | 1 (100) | |||||
| Amikacin NS (1) | 1 (100) | ||||||||||
| Gentamicin S (995) | 58 (5.8) | 777 (83.9) | 147 (98.7) | 11 (99.8) | 1 (99.9) | 1 (100) | |||||
| Gentamicin NS (44) | 1 (2.3) | 30 (70.5) | 9 (90.9) | 2 (95.5) | 1 (97.7) | 1 (100) | |||||
| Tobramycin S (982) | 56 (5.7) | 766 (83.7) | 146 (98.6) | 11 (99.7) | 2 (99.9) | 1 (100) | |||||
| Tobramycin NS (57) | 3 (5.3) | 41 (77.2) | 10 (94.7) | 2 (98.2) | 1 (100) | ||||||
| Pseudomonas aeruginosa | |||||||||||
| Amikacin S (1,688) | 7 (0.4) | 27 (2.0) | 42 (4.5) | 83 (9.4) | 481 (37.9) | 556 (70.9) | 299 (88.6) | 157 (97.9) | 34 (99.9) | 2 (100) | |
| Amikacin NS (101) | 1 (1.0) | 2 (3.0) | 13 (15.8) | 25 (40.6) | 18 (58.4) | 42 (100) | |||||
| Gentamicin S (1,602) | 7 (0.4) | 24 (1.9) | 40 (4.4) | 83 (9.6) | 476 (39.3) | 544 (73.3) | 280 (90.8) | 138 (99.4) | 10 (100) | ||
| Gentamicin NS (187) | 3 (1.6) | 2 (2.7) | 5 (5.3) | 13 (12.3) | 21 (23.5) | 32 (40.6) | 49 (66.8) | 18 (76.5) | 44 (100) | ||
| Tobramycin S (1,686) | 7 (0.4) | 25 (1.9) | 41 (4.3) | 82 (9.2) | 476 (37.4) | 543 (69.6) | 280 (86.2) | 160 (95.7) | 55 (99.0) | 12 (99.7) | 5 (100) |
| Tobramycin NS (103) | 2 (1.9) | 1 (2.9) | 1 (3.9) | 5 (8.7) | 14 (22.3) | 21 (42.7) | 10 (52.4) | 4 (56.3) | 6 (62.1) | 39 (100) | |
a
S, aminoglycoside susceptible; NS, aminoglycoside nonsusceptible.