TABLE 4.
Activity of antimicrobial agents tested against carbapenem-resistant P. aeruginosaa and S. maltophiliab
| Agent | MIC (mg/liter) |
% susceptible | ||
|---|---|---|---|---|
| Range | 50% | 90% | ||
| P. aeruginosa | ||||
| Cefiderocolc | ≤0.03 to 1 | 0.25 | 0.5 | 100 |
| Amikacin | ≤4 to >64 | 64 | >64 | 48 |
| Ciprofloxacin | 2 to >4 | >4 | >4 | 0 |
| Colistin | ≤0.5 to >8 | 1 | 1 | 96 |
| Tigecycline | 1 to >4 | >4 | >4 | 22 |
| Aztreonam | 4 to >32 | 32 | >32 | 22 |
| Ceftolozane-tazobactam | 1 to >64 | >64 | >64 | 26 |
| Cefepime | 8 to >16 | >16 | >16 | 7 |
| Ceftazidime | 16 to >64 | 64 | >64 | 0 |
| Ceftazidime-avibactam | 1 to >64 | 64 | >64 | 8 |
| Meropenem | 2 to >64 | 32 | 64 | 4 |
| S. maltophilia | ||||
| Cefiderocolc | ≤0.03 to 0.25 | 0.06 | 0.25 | 100 |
| Amikacin | ≤4 to >64 | >64 | >64 | —d |
| Ciprofloxacin | 0.5 to >4 | 2 | >4 | — |
| Colistin | ≤0.5 to >8 | 1 | 8 | 68 |
| Tigecycline | ≤0.25 to >4 | 0.5 | 2 | — |
| Aztreonam | >32 | >32 | >32 | — |
| Ceftolozane-tazobactam | 1 to >64 | >64 | >64 | — |
| Cefepime | 8 to >16 | >16 | >16 | — |
| Ceftazidime | 2 to >64 | >64 | >64 | 8 |
| Ceftazidime-avibactam | 0.25 to >64 | 64 | >64 | 16 |
a
Data are for 27 P. aeruginosa isolates. Resistance mechanisms included VIM plus PDC (n = 12) and PDC alone (n = 4).
b
Data are for 25 S. maltophilia isolates. All isolates contained L1 and L2 β-lactamases.
c
Percent susceptible based on a provisional breakpoint of 4 mg/liter.
d
—, no breakpoint is available.