TABLE 4.
Summary of PK parameters for zoliflodacin in plasma and total radioactivity in plasma and whole blood
| Parameter | Value for: |
||
|---|---|---|---|
| Zoliflodacin in plasma (n = 6) |
[14C]Zoliflodacin total radioactivity |
||
| Plasma (n = 6) | Whole blood (n = 6) | ||
| Cmax, ng/ml | 16,370 (26.1) | 27,540 (22.6) | 18,870 (21.9) |
| AUC0-t, h·ng/ml | 148,400 (20.5) | 252,600 (16.8) | 167,600 (17.1) |
| AUC0-∞, h·ng/ml | 148,400 (20.5) | 257,900 (16.8) | 177,900 (16.5) |
| t1/2, h | 6.5 (5.3–8.4) | 7.5 (6.1–10.1) | 6.4 (5.3–9.3) |
| Tmax, ha | 2.5 (1.5–4.0) | 2.5 (2.0–4.0) | 2.5 (1.5–4.0) |
| CL/F, liters/h | 20.2 (20.5) | NC | NC |
| Vz/F, liters | 188.2 (21.5) | NC | NC |
| Ratio | 0.576b | NC | 0.690c |
a
Values are geometric means (%CV or range) unless otherwise specified. Units for Cmax and AUC for total radioactivity are nanogram equivalents per gram and nanogram equivalents per hour per gram, respectively. Values for Tmax are medians (ranges). NC, not calculated.
b
Ratio of zoliflodacin AUC0-∞ in plasma to total radioactivity in plasma.
c
Ratio of zoliflodacin AUC0-∞ for total radioactivity in whole blood to plasma.