TABLE 1.

SYO pooled triazole MIC distributions for species of Candida, Saccharomyces, and Aspergillus^a

Agent and speciesb	No. of isolates	No. of labs used/total no.c	No. of isolates with MIC (µg/ml) ofd:
Fluconazole			0.06	0.12	0.25	0.5	1	2	4	8	16	32	64	≥128
C. albicans	11,171	28/30	12	1,016	4,252	4,152	978	238	122	82	78	33	49	159
Confirmed ERG11 mutants	59	4/4		3	1	4	3		1	2	2		43
C. dubliniensis	195	7/10		48	64	57	13	6	3	2		1	1
C. famata	23	3/6			1	2	11	5	3	1
C. glabrata	4,418	30/30		13	9	23	64	152	375	1,049	1,330	691	216	496
C. guilliermondii	153	8/13		2	1	6	20	36	46	19	10	6	4	3
C. kefyr	55	3/4		13	25	15	2
C. krusei	537	15/16		1	1	1			3	8	43	193	220	67
C. lusitaniae	298	12/12		16	41	75	99	43	12	5	1	4	1	1
C. parapsilosis	3,691	28/30		89	502	1,210	958	421	221	151	82	27	19	11
C. parapsilosis sensu stricto	911	5/5		18	118	282	216	121	74	53	19	6	4
C. metapsilosis	36	4/4			1	2	17	10	5		1
C. orthopsilosis	110	5/5		3	4	29	43	15	8	4	2		1	1
C. tropicalis	1,854	24/28		20	82	270	701	482	129	53	19	24	14	60
S. cerevisiae	244	3/3		4	3	9	40	70	76	26	10	4	2
Itraconazole			0.008	0.01	0.03	0.06	0.12	0.25	0.5	1	2	4	8	≥16
C. albicans	7,843	27/30	69	995	2,696	2,754	905	164	77	27	14	7	9	126
Confirmed ERG11 mutants	59	4/4			2	2	2	5	11	3	7	4		23
C. dubliniensis	125	6/8		13	21	47	27	7	2	5	1			2
C. famata	18	3/5		1	1	2	3	7	3	1
C. glabrata	3,594	29/30		12	19	42	112	428	1,335	910	195	71	26	444
C. guilliermondii	149	9/13		3		8	31	55	37	10	2			3
C. kefyr	45	3/3		5	10	17	12	1
C. krusei	574	13/16		4	3	14	69	283	156	33	2	1		9
C. lusitaniae	171	8/11		11	12	52	60	28	7	1
C. parapsilosis	3,353	23/30		209	570	1,098	1,150	252	59	13	1	1
C. parapsilosis sensu stricto	730	4/5		68	79	237	254	83	6	3
C. metapsilosis	32	4/4		3	3	12	11	1	2
C. orthopsilosis	88	3/4		2	13	35	26	12
C. tropicalis	1,399	23/29		14	51	138	513	508	126	16	4	1	5	23
S. cerevisiae	41	3/3		1	1	3	21	11	2	2
A. niger	233	6/7		18	23	48	69	44	17	6			1	7
Posaconazole			0.008	0.01	0.03	0.06	0.12	0.25	0.5	1	2	4	8	≥16
C. albicans	6,729	27/30	596	2,768	2,318	587	175	96	56	32	10	3	60	28
Confirmed ERG11 mutants	59		1		3	1	4	9	8	7	1	1		24
C. dubliniensis	185	7/8	35	56	63	25	4			2
C. glabrata	2,999	25/29	4	5	28	39	50	153	590	1,145	579	62	251	93
C. guilliermondii	111	9/12	3	1	9	15	27	35	18	3
C. kefyr	40	3/3			7	13	13	5	2
C. krusei	562	13/15	1	1	3	20	90	264	151	25	5		2
C. lusitaniae	172	11/11	17	49	58	36	10		1	1
C. parapsilosis	3,085	26/30	136	538	1,091	915	297	86	11	7	1	1		2
C. parapsilosis sensu stricto	670	5/5	40	127	206	193	69	31	2				2
C. metapsilosis	17	3/4		3	7	4	3
C. orthopsilosis	30	3/4		5	14	7	4
C. tropicalis	1,366	23/29	16	50	107	250	408	336	147	22	6		17	7
S. cerevisiae	41	3/3				3	6	20	9	2	1
Voriconazole			0.008	0.01	0.03	0.06	0.12	0.25	0.5	1	2	4	8	≥16
C. albicans	8,747	29/30	5,947	1,691	481	222	111	82	47	22	10	15	76	43
Confirmed ERG11 mutants	59	4/4	3	4	4	1	4	1	7	6	3	5	2	19
C. dubliniensis	215	7/9	182	21	5	3	1	2			1
C. famata	25	3/5	5	10	4	2	2	2
C. glabrata	3,255	24/30	23	29	65	189	486	911	824	340	136	156	82	14
C. guilliermondii	157	11/12	8	10	32	46	34	10	11	4	1			1
C. kefyr	55	3/3	46	8	1
C. krusei	676	14/16	2	1	1	16	108	291	199	42	11	3	1	1
C. lusitaniae	248	11/12	120	70	32	15	4	1	2	4
C. parapsilosis	2,670	26/30	1,213	695	364	210	103	50	16	10	9
Voriconazole			0.008	0.01	0.03	0.06	0.12	0.25	0.5	1	2	4	8	≥16
C. parapsilosis sensu stricto	718	5/5	261	185	122	80	47	12	5	4	2
C. metapsilosis	30	3/4	2	10	11	4	2	1
C. orthopsilosis	20	3/4	1	8	3	6	2
C. tropicalis	1,637	19/28	45	92	227	466	443	200	70	25	20	9	23	17
S. cerevisiae	41	3/3	1	3	17	15	2	2	1
A. fumigatus	903	8/8	2	7	35	64	157	396	179	33	8	7	7	8
Confirmed cyp51A mutants	39	5/5					3	4	8	3	4	5	2	10
A. flavus	389	6/7	5	1	14	32	89	139	59	29	16	1	0	4
A. niger	74	3/6				1	9	19	33	12
A. terreus	302	5/6	6	5	16	19	48	122	69	15	2

^aIncluding the complexes of C. glabrata, C. parapsilosis, and Aspergillus spp. (the cyp51A mutants are A. fumigatus sensu stricto).

^bNewly accepted taxonomic names or reclassifications are as follows: C. famata (D. hansenii), C. guilliermondii (M. guilliermondii), C. kefyr (K. marxianus), C. krusei (P. kudriavzevii), and Candida lusitaniae (Clavispora lusitaniae).

^cTotal number of laboratories included in the ECV definition pool/total number of laboratories that submitted data.

^dData are from between 3 and 30 laboratories and were determined by the colorimetric broth microdilution SYO method (14); the highest number in each row (showing the most frequent, or mode, MIC) is in bold.