TABLE 2.
Etest triazole pooled MIC distributions for species of Candida and Aspergillusa
| Agent and speciesb | No. of isolates | No. of labs used/total no.c | No. of isolates with MIC (µg/ml) of:d | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fluconazole | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | ≥128 | ||
| C. glabrata | 356 | 7/10 | 1 | 4 | 13 | 34 | 50 | 79 | 88 | 36 | 13 | 28 | 10 | ||
| C. parapsilosis | 639 | 9/9 | 3 | 19 | 68 | 131 | 153 | 138 | 66 | 21 | 9 | 7 | 20 | 4 | |
| C. tropicalis | 368 | 9/10 | 3 | 5 | 11 | 61 | 96 | 120 | 47 | 11 | 4 | 1 | 4 | 4 | 1 |
| Itraconazole | ≤0.004 | 0.008 | 0.01 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | ≥16 | ||
| C. albicans | 975 | 8/9 | 7 | 55 | 145 | 237 | 295 | 150 | 27 | 19 | 16 | 6 | 7 | 5 | 6 |
| C. krusei | 101 | 3/3 | 1 | 2 | 9 | 36 | 35 | 7 | 7 | 1 | 3 | ||||
| C. tropicalis | 165 | 5/8 | 2 | 12 | 23 | 39 | 30 | 22 | 15 | 11 | 7 | 2 | 1 | 1 | |
| A. fumigatus | 1,112 | 10/10 | 4 | 1 | 3 | 30 | 56 | 157 | 483 | 268 | 73 | 12 | 5 | 20 | |
| Confirmed cyp51A mutants | 81 | 8/8 | 1 | 1 | 1 | 7 | 4 | 67 | |||||||
| A. flavus | 250 | 7/8 | 1 | 4 | 19 | 37 | 103 | 69 | 16 | 1 | |||||
| A. nidulans | 130 | 4/4 | 1 | 1 | 13 | 39 | 34 | 23 | 11 | 7 | 1 | ||||
| A. niger | 176 | 4/5 | 1 | 1 | 2 | 5 | 25 | 71 | 45 | 17 | 5 | 4 | |||
| Posaconazole | ≤0.004 | 0.008 | 0.01 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | ≥16 | ||
| C. albicans | 305 | 4/6 | 6 | 29 | 94 | 102 | 44 | 17 | 9 | 3 | 1 | ||||
| C. krusei | 48 | 3/3 | 1 | 5 | 17 | 16 | 7 | 2 | |||||||
| C. parapsilosis | 162 | 4/5 | 8 | 26 | 51 | 37 | 23 | 9 | 3 | 2 | 1 | 2 | |||
| C. tropicalis | 101 | 4/5 | 9 | 21 | 32 | 21 | 4 | 8 | 3 | 1 | 1 | 1 | |||
| A. flavus | 204 | 7/7 | 1 | 4 | 14 | 70 | 96 | 17 | 2 | ||||||
| A. niger | 168 | 4/5 | 5 | 16 | 58 | 73 | 15 | 1 | |||||||
| A. terreus | 194 | 5/5 | 8 | 47 | 105 | 27 | 4 | 2 | 1 | ||||||
| Voriconazole | ≤0.004 | 0.008 | 0.01 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | ≥16 | ||
| C. albicans | 2,159 | 8/11 | 485 | 803 | 491 | 158 | 104 | 42 | 22 | 20 | 11 | 5 | 7 | 1 | 10 |
| C. glabrata | 551 | 8/9 | 7 | 11 | 20 | 37 | 105 | 143 | 96 | 63 | 30 | 15 | 14 | 10 | |
| C. krusei | 130 | 6/6 | 1 | 2 | 3 | 20 | 30 | 45 | 24 | 5 | 2 | ||||
| C. parapsilosis | 506 | 7/9 | 4 | 20 | 46 | 97 | 167 | 100 | 39 | 15 | 4 | 4 | 8 | 1 | 1 |
| C. tropicalis | 260 | 6/10 | 4 | 4 | 12 | 28 | 82 | 88 | 22 | 14 | 5 | 1 | |||
| A. fumigatus | 1,409 | 11/11 | 1 | 6 | 2 | 30 | 132 | 633 | 473 | 100 | 19 | 7 | 3 | 2 | 1 |
| Confirmed cyp51A mutants | 75 | 8/8 | 5 | 6 | 7 | 8 | 13 | 15 | 3 | 1 | 17 | ||||
| A. flavus | 257 | 7/7 | 1 | 18 | 84 | 103 | 39 | 10 | 1 | 1 | |||||
| A. niger | 173 | 4/5 | 2 | 3 | 22 | 37 | 81 | 25 | 1 | 1 | 1 | ||||
a
Including the complexes of C. parapsilosis, C. glabrata, and Aspergillus species (the cyp51A mutants are A. fumigatus sensu stricto).
b
Newly accepted taxonomic name or reclassification: C. krusei (P. kudriavzevii).
c
Total number of laboratories included in the ECV definition pool/total number of study laboratories and one published study (20) that submitted data.
d
Data are from between 3 and 11 laboratories and were determined by the agar diffusion Etest method (15); the highest number in each row (showing the most frequent, or mode, MIC) is in bold.