TABLE 3.
Method-dependent SYO ECOFFinder ECVs of four triazoles for species of Candida, Saccharomyces, and Aspergillusa
| Agent and speciesb | No. of isolates | No. of labs used/total no. | MIC (µg/ml) |
ECV (µg/ml)c | |
|---|---|---|---|---|---|
| Range | Mode | ||||
| Fluconazole | |||||
| C. albicans | 11,171 | 28/30 | 0.06 to ≥128 | 0.25 | 1 |
| C. dubliniensis | 195 | 7/10 | 0.12 to 64 | 0.25 | 1 |
| C. glabrata | 4,418 | 30/30 | 0.12 to ≥128 | 16 | 64 |
| C. guilliermondii | 153 | 8/13 | 0.12 to ≥128 | 4 | 16 |
| C. krusei | 537 | 15/16 | 0.12 to ≥128 | 64 | 128 |
| C. lusitaniae | 298 | 12/12 | 0.12 to ≥128 | 1 | 4 |
| C. parapsilosis | 3,691 | 28/30 | 0.12 to ≥128 | 0.5 | 2 |
| C. parapsilosis sensu stricto | 911 | 5/5 | 0.12 to 64 | 0.5 | 2 |
| C. orthopsilosis | 110 | 5/5 | 0.12 to ≥128 | 1 | 4 |
| C. tropicalis | 1,854 | 24/28 | 0.12 to ≥128 | 1 | 4 |
| S. cerevisiae | 244 | 3/3 | 0.12 to 64 | 4 | 16 |
| Itraconazole | |||||
| C. albicans | 7,843 | 27/30 | 0.008 to ≥16 | 0.06 | 0.12 |
| C. dubliniensis | 125 | 6/8 | 0.01 to ≥16 | 0.06 | 0.25 |
| C. glabrata | 3,594 | 29/30 | 0.01 to ≥16 | 0.5 | 2 |
| C. guilliermondii | 149 | 9/13 | 0.01 to ≥16 | 0.25 | 1 |
| C. krusei | 574 | 13/16 | 0.01 to ≥16 | 0.25 | 1 |
| C. lusitaniae | 171 | 8/11 | 0.01 to 1 | 0.12 | 0.5 |
| C. parapsilosis | 3,353 | 23/30 | 0.01 to 4 | 0.12 | 0.25 |
| C. parapsilosis sensu stricto | 730 | 4/5 | 0.01 to 1 | 0.12 | 0.5 |
| C. tropicalis | 1,399 | 23/29 | 0.01 to ≥16 | 0.12 | 0.5 |
| A. niger | 233 | 6/7 | 0.01 to ≥16 | 0.12 | 1 |
| Posaconazole | |||||
| C. albicans | 6,729 | 27/30 | 0.008 to ≥16 | 0.01 | 0.06 |
| C. dubliniensis | 185 | 7/8 | 0.008 to 1 | 0.03 | 0.12 |
| C. glabrata | 2,999 | 25/29 | 0.008 to ≥16 | 1 | 4 |
| C. guilliermondii | 111 | 9/12 | 0.008 to 1 | 0.25 | 1 |
| C. krusei | 562 | 13/15 | 0.008 to 8 | 0.25 | 1 |
| C. lusitaniae | 172 | 11/11 | 0.008 to 1 | 0.03 | 0.12 |
| C. parapsilosis | 3,085 | 26/30 | 0.008 to ≥16 | 0.03 | 0.12 |
| C. parapsilosis sensu stricto | 670 | 5/5 | 0.008 to 8 | 0.03 | 0.25 |
| C. tropicalis | 1,366 | 23/29 | 0.008 to ≥16 | 0.12 | 1 |
| Voriconazole | |||||
| C. albicans | 8,747 | 29/30 | 0.008 to ≥16 | 0.008 | 0.01d |
| C. dubliniensis | 215 | 7/9 | 0.008 to 2 | 0.008 | 0.01d |
| C. glabrata | 3,255 | 24/30 | 0.008 to ≥16 | 0.25 | 2 |
| C. guilliermondii | 157 | 11/12 | 0.008 to ≥16 | 0.06 | 0.5 |
| C. krusei | 676 | 14/16 | 0.008 to ≥16 | 0.25 | 1 |
| C. lusitaniae | 248 | 11/12 | 0.008 to 1 | 0.008 | 0.03d |
| C. parapsilosis | 2670 | 26/30 | 0.008 to 2 | 0.008 | 0.01d |
| C. parapsilosis sensu stricto | 718 | 5/5 | 0.008 to 2 | 0.008 | 0.03d |
| C. tropicalis | 1,637 | 19/28 | 0.008 to ≥16 | 0.06 | 0.5 |
| A. fumigatus | 903 | 8/8 | 0.008 to ≥16 | 0.25 | 1 |
| A. flavus | 389 | 6/7 | 0.008 to ≥16 | 0.25 | 1 |
| A. terreus | 302 | 5/6 | 0.008 to 2 | 0.25 | 1 |
Including the complexes of C. parapsilosis, C. glabrata, and Aspergillus species. Modal variability or insufficient data precluded the proposal of ECVs for some species of both Candida and Aspergillus.
Newly accepted taxonomic names or reclassifications are as follows: C. guilliermondii (M. guilliermondii), C. krusei (P. kudriavzevii), and Candida lusitaniae (Clavispora lusitaniae).
ECOFFinder ECVs for 97.5% of the statistically modeled population based on MICs obtained by the colorimetric broth microdilution SYO method (14, 29), except where indicated by a superscript c, referring to footnote c. The proposed method-dependent SYO ECV for A. fumigatus and posaconazole is 0.06 µg/ml, as reported elsewhere (23). C. krusei is intrinsically resistant to fluconazole regardless of the MIC.
ECV as estimated using the second derivative method (30).