TABLE 6.
Antiviral activities of NVR 3-778 and LMV in PHH during de novo infectiona
| Molecule | NVR 3-778 |
LMV |
||
|---|---|---|---|---|
| EC50 (µM) | EC90 (µM) | EC50 (µM) | EC90 (µM) | |
| HBV DNA | 0.81 ± 0.18 | 5.4 ± 2.0 | 0.016 ± 0.010 | 0.066 ± 0.010 |
| HBsAg | 4.8 ± 0.98 | 10.2 ± 3.0 | >30 | >30 |
| HBeAg | 4.5 ± 0.82 | 8.9 ± 1.2 | >30 | >30 |
| Intracellular HBV RNA | 3.7 ± 0.22 | 11.6 ± 2.7 | >30 | >30 |
| β-Actin mRNA | 10 μM < CC50 <30 μMb | 10 μM < CC90 <30 μMb | >30 | >30 |
a
Mean EC50 values and standard deviations were determined using PHH from three different donors. CC50, 50% cytotoxic concentration.
b
Inhibition of β-actin mRNA by NVR 3-778 was observed only at the highest concentration tested (30 μM).