TABLE 1.
Distribution of different Candida auris EGR11 and FKS1 HS1 variant MICs
Gene variant | MIC range (mode) (mg/liter) for: |
||||
---|---|---|---|---|---|
Fluconazole | Voriconazole | Micafungin | Anidulafungin | Caspofungin | |
ERG11 substitutions | |||||
WT | 2 to 64 (2) | 0.03 to 1 (0.06) | |||
Y132F | 64 to >128 (>128) | 2 to >16 (4) | |||
K143R | 32 to >128 (>128) | 0.12 to 1 (0.5) | |||
FKS1 HS1 substitutions | |||||
WT | 0.03 to 0.5 (0.125) | 0.03 to 1 (0.5) | 0.125 to 1 (0.25) | ||
S639F | 16 | 4 to >16 (>16) | 8 to 16 (8) |