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Linear mixed-effects analysis of CLR and CLsys versus CLCR for renal impairment subjects
| Compound | Parameter | Mixed-effect model | Mean slope | Lower CI | Upper CI | P value |
|---|---|---|---|---|---|---|
| FEP | CLR | Intercept + CLCR | 1.10 | 0.82 | 1.37 | <0.0001 |
| ZID | 1.13 | 0.88 | 1.37 | <0.0001 | ||
| FEP | CLsys | Intercept + CLCR | 0.84 | 0.69 | 0.99 | <0.0001 |
| ZID | 1.09 | 0.90 | 1.28 | <0.0001 |
