TABLE 2.
Plasma pharmacokinetic parameters after oral dosing in micea
| Compound | Dose (mg/kg) | Cmax (µM) | Tmax (h) | t1/2 (h) | AUC (µM·h) | Concn at 24 h (µM) | Fraction unbound |
|---|---|---|---|---|---|---|---|
| AS | 10 | 0.05 | 0.25 | Could not determine | Could not determine | <0.013 | Not measured |
| DHAb | 0.35 | 0.25 | Could not determine | 0.32 | <0.018 | 0.22 | |
| OZ418 | 10 | 27 | 1 | 3.4 | 268 | 3.03 | 0.0063 |
a
Cmax, maximum concentration in plasma; Tmax, time to maximum concentration in plasma; t1/2, half-life; AUC, area under the concentration-time curve.
b
DHA is the active metabolite of AS.