TABLE 3.
Studies evaluating cefiderocol against CRABa
| Reference no. | β-Lactamase(s) | No. of CRAB isolates | No. of isolates with MIC >4 or 8 μg/mlb | MIC data (μg/ml) |
||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | Range | ||||
| 35 | OXA | 101 | NA | 0.25 | 1 | ≤0.03 to >64 |
| 36 | NA | 368 | 38 | 0.25 | 8 | 0.015 to >256 |
| 37 | NA | 173 (NoA)c | 24 | 0.25 | 1 | ≤0.002 to 8 |
| 595 (EU) | 0.12 | 1 | 0.004 to 64 | |||
| 41 | NDM | 2 | 0 | NA | 4 | NA |
| OXA-23 | 543 | 15 | 0.12 | 1 | ≤0.02 to 16 | |
| OXA-40 | 124 | 6 | 0.12 | 1 | 0.04 to 64 | |
| OXA-58 | 13 | 0 | 0.12 | 1 | 0.06 to 1 | |
| GES | 7 | 1 | NA | NA | 0.25 to 8 | |
| 42 | NA | 558 | 22 | 0.5 | 2 | ≤0.002 to >256 |
| 136 | NA | 44 | 0 | 0.12 | 1 | 0.015 to 4 |
| 44 | NA | 758 | 28 | NA | 1 | ≤0.004 to 64 |
| 39 | OXA-23 | 1 | NA | NA | 0.063 | NA |
| OXA-58 | 1 | NA | NA | 1 | NA | |
| OXA-26, OXA-51-like | 1 | NA | NA | 0.5 | NA | |
| OXA-51-like | 1 | NA | NA | 0.5 | NA | |
| OXA-23, OXA-51-like | 1 | NA | NA | ≤0.031 | NA | |
| OXA-48 | 1 | NA | NA | ≤0.031 | NA | |
| 45 | NA | 107 | 0 | 0.06 | 0.5 | 0.03 to 2 |
| 38 | OXA-23/-40/-58/-72 | 85 | 7 | 0.12 | 4 | 0.03 to 64 |
| NDM-1, IMP-4 | 2 | NA | NA | NA | NA | |
| 137 | OXA-23 | 5 | 0 | NA | NA | 0.03 to 0.5 |
| 40 | Random strains | 104 | 0 | 0.125 | 2 | ≤0.063 to 4 |
| All BL carriers | 29 | 0 | 0.5 | 8 | 0.03 to >32 | |
| IMP-1 | 2 | 0 | NA | NA | 0.12 to 0.25 | |
| OXA-23 | 12 | 2 | NA | NA | 0.03 to >32 | |
| OXA-24 | 8 | 1 | NA | NA | 0.12 to 8 | |
| OXA-51/ISAba1 | 2 | 0 | NA | NA | 0.5 to 1 | |
| OXA-58 | 5 | 0 | NA | NA | 0.12 to 4 | |