TABLE 4.

Studies evaluating eravacycline against CRAB

Reference no.	β-Lactamase(s)	No. of CRAB isolates	No. of isolates with MIC >4 μg/ml	MIC data (μg/ml)
				MIC50	MIC90	Range
56		163		0.5	1	0.12–8
59		55		0.5	1	0.031–2
28	OXA-23	231		0.5	1
	OXA-40	17		0.25	1
	OXA-58	27		0.5	0.5
	OXA-51a	9				0.125–0.5
	Overall	286b	1	0.5	1	≤0.06–8
57	NDM	5	0			0.13–0.25
	OXA-23/-40/-51/-58	39	0	0.5	1	≤0.06–2
	Tigr plus OXA-23c	5	2	4	8	1.0–8.0
	Overall	59d	2	0.5	1	≤0.06–8
58	OXA-23	58			1
	OXA-24	2
	KPC	1
	adeB expression	38e		0.5	2	0.06–4
	Overall	158f		0.5	1	≤0.015–8
61	NDM	62
	OXA-48	27
	VIM	15
	Overall	104		0.5	4
138	OXA	8
	NDM	4
	Total	14		0.25	1	0.031–2
139		193		1	2	0.12–8
62	NDM, OXA-48, VIM	16		0.125	8
60		707		1	2	0.06–8
140		52		0.5	2	≤0.016–4

^aHyperproduced.

^bOne isolate with OXA-23 and OXA-58, 1 isolate with NDM-1.

^cTig^r, tigecycline resistant.

^dForty-nine CRAB isolates and 10 carbapenem-susceptible A. baumannii isolates.

^eTwenty-six CRAB isolates and 12 carbapenem-susceptible A. baumannii isolates.

^fOne hundred nine CRAB isolates and 49 carbapenem-susceptible A. baumannii isolates.