Figure 3.

Quenching of transduction activity in bleached Gcaps^−/− rods after pigment regeneration. A, Current recorded in darkness from a rod after 1.4% rhodopsin bleach and 3 h incubation with vehicle for control (bleached + vehicle) or with 100 μm exogenous 11-cis-retinal (bleached +11-cis-retinal). B, Averaged power spectra of the dark current recorded from rods after 1.4% rhodopsin bleach and incubation in darkness for 3 h with vehicle (bleached +vehicle, open black squares, n = 6) or with 100 μm exogenous 11-cis-retinal (bleached +11-cis-retinal, open red squares, n = 6). The red dashed line represents the power spectrum of dark-adapted Gcaps^−/− rods from Figure 1D for comparison. Plots are shown as mean ± SEM.