Table 2.
Modulation of DMBA induced impairment of membrane bound ATPases by betulinic acid among different treatment groups of female Sprague Dawley rats.
| Parameter | Group I | Group II | Group III | Group IV | Group V | Group VI | F-ratio | HSD value |
|---|---|---|---|---|---|---|---|---|
| Na+/K+-ATPase | ||||||||
| (μmoles of phosphate | ||||||||
| liberated/min/mg protein) | ||||||||
| Stomach | 67.120a ±0.329 | 185.821b±0.616 | 26.890c±0.0587 | 102.770d±1.017 | 32.830e±0.386 | 157.250f±0.673 | 5.064* | 0.1528 |
| Lung | 29.698a±0.587 | 60.836b±0.210 | 31.815c±0.645 | 31.388d±0.732 | 40.535e±0.711 | 39.493f±0.268 | 27.270* | 0.0546 |
| Ca2+-ATPase | ||||||||
| (μmoles of phosphate | ||||||||
| liberated/min/mg protein) | ||||||||
| Stomach | 111.285±0.501 | 254.410±0.386 | 61.863±0.243 | 105.80±0.558 | 31.913±0.558 | 136.503±0.616 | 1.731 | - |
| Lung | 50.231±0.036 | 57.348±0.674 | 104.054±0.674 | 54.424±0.471 | 91.757±0.384 | 62.890±0.645 | 1.043 | - |
| Mg2+-ATPase | ||||||||
| (μmoles of phosphate | ||||||||
| liberated/min/mg protein) | ||||||||
| Stomach | 71.060a±1.959 | 137.650b±1.80 | 97.80c±2.458 | 141.190d±0.2358 | 40.940e±2.344 | 135.490f±1.732 | 3.458* | 0.2830 |
| Lung | 44.360a±0.442 | 60.950b±0.645 | 55.460c±0.181 | 56.060d±0.529 | 147.950e±0.7011 | 52.750f±0.501 | 12.063* | 0.1482 |
*Represents significance at P≤0.05. Superscripts a-f represents comparison of group I, II, III, IV, V and VI means using HSD value.